Polopo CEO Maya Sapir Mir

Polopo CEO Maya Sapir Mir

Opinion

Op Ed: Maya Sapir-Mir, PhD, CEO and Co-Founder of PoLoPo, on Growing Animal Proteins from Potatoes

Maya Sapir-Mir is CEO and co-founder of PoLoPo, a molecular farming pioneer producing proteins directly in common crops, beginning with egg protein (ovalbumin) grown in potatoes. PoLoPo last year raised $2.3 million in pre-seed funding and recently unveiled its molecular farming platform, SuperAA, for producing key proteins ovalbumin and patatin. Maya has nearly ten years of experience in the biotech industry and agricultural R&D and holds a PhD in plant sciences from the Hebrew University of Jerusalem. She performed post-doctoral work at the Volcani Institute, Israel’s leading agricultural R&D facility, in protein identification, extraction, and characterization in plants and microorganisms. Here, she explains the importance of this emerging biotechnology; “Instead of inefficiently growing plants to feed animals crowded in factory farms, molecular farming gives us …

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EFISHient Protein, announces that it has achieved a significant milestone with the successful development of the Tilapia cell line.

Courtesy of EFISHient Protein, image credit Roee Shpernik

Cultivated Seafood

EFISHient Protein Achieves Milestone in Tilapia Cell Line Development

Israel’s leading cultivated fish startup, EFISHient Protein, announces that it has achieved a significant milestone with the successful development of the cell line of the water fish Tilapia. EFISHient Protein says that it is establishing a genetic cell bank by leveraging its advanced technology to produce muscle and fat cells of the sought-after fish. This achievement in cell line development comes after the successful creation of a cultivated tilapia fillet prototype, which was achieved ahead of schedule last year. According to the company, both achievements highlight its dedication and support for an environmentally friendly fish industry on a global scale. Dana Levin, CEO of EFISHient Protein, shared, “Completing the Tilapia cell line development showcases our dedication to accelerating sustainable protein solutions, ensuring future generations can enjoy nutritious and …

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Finally Foods utilize plants as "bioreactors," modifying them with cutting-edge technology to grow sustainable alternatives to animal-based proteins, starting with casein to make cheese.

© Finally Foods

Cultivated, Cell-Cultured & Biotechnology

Finally Foods Secures Funds for AI-Driven Plant Molecular Tech to Produce Casein for Cheese

Israeli startup Finally Foods Ltd., an AI-driven company focused on revolutionizing the alt-protein sector through plant molecular farming, has secured pre-seed funding from The Kitchen FoodTech Hub (TKH) and the Israeli Innovation Authority (IIA).  Finally Foods utilizes potatoes as “bioreactors,” modifying them with cutting-edge technology to grow sustainable alternatives to animal-based proteins. It will start by producing casein, the key protein to make “cheese that’s gentle on our planet and a joy for the taste buds.” The new company leverages AI technology developed by the Israeli computational biology company Evogene. This technology enables the rapid discovery and development of biological markers for genetic engineering and other applications. It also promises short R&D cycles and a swift path to market. Sustainable future According to the announcement, …

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A close up of a man's hands tearing apart a piece of 3D printer plant-based beef steak to show the muscle-like fibres.

© Steakholder Foods

Printed Technology

Steakholder Foods Enters US Market with Ready Blends for 3D Plant-Based Meat and Fish

Israeli bioprinting technology expert Steakholder Foods (Nasdaq: STKH) has entered the US market with the launch of SHMeat and SHFish; blended dried extracts of ingredients ready for mixing to create 3D plant-based alternatives. The initial blends, Beef Steak and White Fish have been developed to replicate the taste and texture of traditional meat while delivering superior quality and flavor. Steakholder Foods plans to expand its plant-based offering with a range of other “exciting” blends to cater to various culinary preferences: Beef Asado, Beef Tenderloin, Beef Flank, Chicken Fillet, and Salmon. According to the announcement, all the ingredients of the new blends have already achieved Generally Recognized as Safe (GRAS) status, underscoring the company’s dedication to consumer health and safety. This move marks the company’s first step …

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Supermeat Cultivated Chicken Sandwich

© SuperMeat

Cultivated Meat

SuperMeat’s Cultivated Chicken Outperforms Most Efficient Farm Animal in Carbon Footprint Study

Chicken is considered the most efficient source of land-animal protein compared to beef and pork due to its lower feed conversion ratio and smaller environmental footprint. However, cultivated chicken presents an opportunity for even greater sustainability. A new life cycle analysis (LCA) from the Israeli startup SuperMeat, conducted by independent research consultancy CE Delft about the environmental impact of its 100% cultivated chicken vs. conventional chicken, found a 47% reduction in carbon emissions when the production used renewable energy. The LCA focused on large-scale production anticipated at the start of the next decade in a scenario where SuperMeat’s production integrates renewable energy within its facility, supply chain, utilities, and medium. Meanwhile, chicken production was based on obtaining soy from deforestation-free supply chains and utilizing renewable …

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PoLoPo unveils its SuperAA plant molecular farming platform already deployed in potato plants at a greenhouse scale.

Image courtesy of PoLoPo

Cultivated, Cell-Cultured & Biotechnology

PoLoPo Unveils Molecular Farming Platform in Potato Plants to Grow Egg Proteins

Last year, the Israeli agrifood startup PoLoPo raised $2.3 million, including $1.75 million in a pre-seed funding round to further develop its plant molecular farming technology for producing animal proteins in potatoes. Now, the startup unveils its molecular farming platform, SuperAA, already deployed in potato plants at a greenhouse scale. The initial focus of PoLoPo’s platform will be producing two key proteins: ovalbumin and patatin (the natural protein in potatoes). Ovalbumin, widely used in packaged foods for its functional properties, presents an affordable alternative to the industry amidst increasing egg prices and supply chain disruptions.  On the other hand, a patatin powder offers allergen-free protein suitable for various food products, from plant-based alternatives, such as DUG potato milk, to sports nutrition and nutraceuticals. Plant molecular farming is also used …

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Crepes filled with animal-free cream

© Imagindairy

Fermentation

Imagindairy and Ginkgo Bioworks Receive Grant to Accelerate the Launch of Cow-Free Dairy Proteins

Israeli animal-free dairy protein developer Imagindairy and Ginkgo Bioworks (NYSE: DNA), a Boston-based biotech specializing in cell programming, announce a partnership to accelerate the introduction of a new wave of cow-free dairy. A joint grant from the Board of Governors of the Israel-US Binational Industrial Research and Development (BIRD) Foundation has partly funded the companies’s multiyear program to commercialize non-whey proteins. The collaboration will leverage Ginkgo Bioworks’ Protein Expression Services and Imagindairy’s process development and scale-up expertise to develop and manufacture animal-free whey cost-effectively to reach prices similar to dairy proteins.  Ginkgo is also working with the Chicago-based alt-seafood producer Aqua Cultured Foods to improve the economics and functions of its microbial strains for large-scale operations. Jennifer Wipf, CEO at Ginkgo Bioworks, shares, “Being awarded this …

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Pluri announces that it has secured a patent from the Israel Patent Office for its System for its 3D bioreactor plant cells technology.

© Pluri

Company News

Pluri Receives First-Ever Patent for 3D Bioreactor Technology in Plant Cell Cultivation

Pluri (Nasdaq:PLUR) (TASE:PLUR), parent company of the recently launched cell-based coffee biotech PluriAgtech, announces that it has secured a patent from the Israel Patent Office for its “System for 3D Cultivation of Plant Cells and Methods of Use.” Pluri claims this is the first-ever patent approval for 3D bioreactor technology in plant cell cultivation. Pluri’s 3D technology enables the cultivation of plant cells in bioreactors to develop sustainable and disease-free plant material for various sectors, from sustainable agriculture to healthcare.   According to the company,  approximately one-fifth of the 50,000 medical plants used today are on a list of threatened species, while climate change and restricted access to fresh water threaten temperature-sensitive crops such as coffee and cacao. Yaky Yanay, Pluri’s CEO and President, commented: “PluriAgtech’s patented …

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Pluri develops cell-based coffee at industrial scale

© Pluri

Cultivated, Cell-Cultured & Biotechnology

PluriAgtech Introduces Cell-Based Coffee to Provide an Alternative to Traditional Production

Israeli biotechnology firm Pluri, formerly Pluristem, (Nasdaq, TASE: PLUR) has launched PluriAgtech, a subsidiary leveraging plant cell culture to grow sustainable coffee and break away from traditional farming methods.  As global warming continues to impact the coffee industry, shrinking viable land for cultivation and increasing demand leads to higher prices and less production.  According to the company, by 2050, land for coffee production will be reduced by half, and 30% must shift to higher altitudes since Arabica plants are temperature-sensitive. Moreover, the rising demand for coffee significantly impacts the environment, resulting in deforestation and increased water and pesticide use.  PluriAgtech claims it can produce high-quality “real” coffee at scale while reducing water usage by 98% and growing areas by 95%, thus preventing deforestation and making …

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© Day 8

Ingredients

Israel’s Day 8 Secures Funds for Leaf Protein-Based Ingredient Extracted from Upcycled Crops

Israeli startup Day 8 has secured $750,000 pre-seed funding from The Kitchen FoodTech Hub to introduce a functional ingredient made from the leaf protein Rubisco for plant-based dairy, meat, and other food applications. The young startup was founded last year by Daniel Rejzner (CEO) and a former executive at Solbar (a leading soy manufacturer) Dana Marom (CTO) to unlock the future of delicious plant-based foods with earth’s most abundant and nutritious protein, Rubisco. All green leaves, from spinach to kale to the small Lemna (duckweed), contain small quantities of Rubisco. Day 8 claims that it has developed a unique extraction method to produce a flavorless white powder that contains the best nutritional qualities of Rubisco and its functional capabilities, such as emulsifying, foaming, and gelling, which surpass the capabilities …

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Aleph Farms meat on dressed table

© Aleph Farms

Cultivated Meat

Aleph Farms Partners with Biomanufacturing Experts to Build Large-Scale Cultivated Meat Facility in Thailand

Cultivated beef company Aleph Farms has partnered with biomanufacturing experts BBGI and Fermbox Bio to produce cultivated meat at Thailand’s first production plant for cellular agriculture applications. Through the partnership, the companies aim to advance the development and production of cultivated meat in the region by focusing on production enhancement, cost optimization, and operational scale-up. BBGI is a Bio-Based Green Innovation company that manufactures and distributes bio-based fuel and high-value and well-being products. Fermbox Bio is a synthetic biology research and manufacturing company leveraging microbial fermentation and synthetic biology to create sustainable products, including cell media ingredients. Both companies have extensive experience in large-scale biomanufacturing design and operation.  “We are excited to be part of this partnership — bringing together people and companies from across the world with …

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SimpliiGood unveils spirulina filament technology

© SimpliiGood 

Algae, Microalgae & Seaweed

SimpliiGood Unveils Spirulina-Derived Filaments to Mimic the Texture of Meat and Fish

Israeli spirulina specialist SimpliiGood has become a trailblazer in the plant-based sector by developing chicken and salmon alternatives using its flagship microalgae ingredient.  As it continues to innovate, the company has recently unveiled a new technology to mimic the texture of meat products: spirulina-derived filaments.  Baruch Dach, founder and CTO at AlgaeCore technologies, SimpliiGood’s parent company, explains that they leverage spirulina-based edible tissue engineering to make the spirulina filaments to be used as an ingredient or base for plant-based meat.  Dach says the ingredient is unique because it contains spirulina cell matrices, not just plain protein, making it versatile and easy to transform into fibers. Meanwhile, these fibers retain their properties even when subjected to high temperatures or freeze-thaw cycles.  Moreover, depending on the application, the ingredient provides over …

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a 3-d printed steak on a plate

© Redefine Meat

Printed Technology

Redefine Meat Uncovers How its Plant-Based Tissue Engineering Tech Mimics Meat in New White Paper

Redefine Meat has published a manuscript in Frontiers that reveals the technology and science behind its plant-based New Meat products. Authored by Daniel Dikovsky, Redefine Meat’s CTO, the paper introduces the company’s novel Plant-Based Tissue Engineering (PBTE) approach to demonstrate how it effectively replicates “the mechanical integrity, texture, and sensory attributes of traditional meat.” According to Dikovsky, meat is among the most challenging foods to replicate, as it encompasses a complex matrix of muscle fibers, fat, and connective tissues that contribute to its unique taste, texture, and overall sensory experience. The manuscript showcases how manipulating plant-based materials at the microstructural level can create complex, multi-component systems that closely resemble meat. According to the author, this approach aligns with Soft Matter principles, which focus on manipulating structures …

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Myodenovo aims to grows cultivated meat using plant-based scaffolds

© Ilia-Nesolenyi-stock.adobe.com

Cultivated, Cell-Cultured & Biotechnology

ProFuse Technology Launches Pioneering Bovine Cell Line for Cultivated Beef

ProFuse Technology, an Israeli biotech specializing in muscle tissue growth, announces the launch of a new bovine cell line for cultivating beef. Branded as PROFUSE-B8 and claimed as a pioneering development, the cell line arises from spontaneously immortalized bovine myoblast cells without using genetic modification technology. As explained by the firm, the bovine cell line has undergone extensive research and testing over two years, resulting in a stable and robust foundation for developing scalable and repeatable muscle-growing processes. Moreover, when combined with the PROFUSE-S1, a muscle differentiation media supplement, the B8 cell line is said to accelerate muscle tissue production, increasing efficiency in shorter times.  Enhancing muscle growth  Established in 2021 by Tamar Eigler-Hirsh, CTO and co-founder, and Guy Nevo Michrowski, the company’s CEO; ProFuse …

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Steakholder Foods and Wyler Farms, Israel's leading tofu producer, have partnered to produce 3D printed plant-based beef steaks.

© Steakholder Foods

Printed Technology

Steakholder Foods and Wyler Farms Partner to Launch 3D Printed Plant-Based Beef Steaks at Industrial Scale

Israeli bioprinting technology expert Steakholder Foods (Nasdaq: STKH) and Wyler Farms, Israel’s leading tofu producer, have signed a memorandum of understanding (MOU) to use industrial-scale 3D printing technology to produce 3D printed plant-based beef steaks. As part of the agreement, Wyler Farms will acquire Steakholder Foods’ 3D Fusion Pro meat printer and a subscription to the SH Software and NutriBlend ink designed explicitly for plant-based meat.  The deal, valued at millions of dollars over the coming years, represents Steakholder Foods’ first commercial partnership in the private sector. The completion of the Fusion Pro 3D printer installation is anticipated to fall between Q4 2024 and Q1 2025, according to the announcement. Arik Kaufman, CEO of Steakholder Foods, comments: “We’re not just showcasing our technology’s potential – we’re …

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Remilk has become the first company to receive the green light in Canada for a precision fermentation-derived protein.

Image courtesy of Remilk

Fermentation

Remilk Receives No Objections Letter for Sale of Animal-Free Milk Protein, Heralding “New-Dairy Revolution” in Canada

Israeli biotech company Remilk announces that it has obtained Health Canada’s “Letter of No Objection,” allowing the use and commercialization of its animal-free milk protein called BLG within Canada. With this achievement, Remilk has become the first company to receive the green light in the country for a precision fermentation-derived protein.  According to the announcement, Health Canada conducted a thorough evaluation and deemed Remilk’s animal-free protein safe for consumption. As a result, Canada has opened the door for new dairy products, including milk, ice cream, yogurt, and cream cheese, made with novel proteins instead of traditional milk proteins. “This is an important day for us at Remilk, and a historic one for Canada as it opens its doors to the new-dairy revolution. We developed a strategic roadmap for …

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Chunk Foods 6oz plant-based steak

Supplied by Chunk Foods

Investments & Acquisitions

Chunk Foods Secures $7.5M Amid Strategic Collab with Better Balance for Vegan Whole Cuts

Better Balance, a plant-based subsidiary of Mexico-based multinational food processing company Sigma Alimentos, one of Latin America’s largest meat and dairy producers, announces a strategic partnership with New York-headquartered startup Chunk Foods to develop co-branded plant-based whole cuts for the Latin American market. The strategic collaboration follows a $7.5 million seed extension for Chunk Foods led by Cheyenne Ventures, which the startup says reflects “ongoing investor confidence” in its vision as well as the potential of plant-based whole cuts. The extension brings the seed round to a total raise of $22M, making it one of the largest seed rounds in the alt protein category, according to the company. Through the alliance, Chunk is set to develop a new line of co-branded plant-based whole-cut meats, marking …

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Cultivated eel dishes created by the vegan restaurant Saido.

© Anatoly Michaello

Cultivated Seafood

Forsea Develops World’s First Cultivated Eel Fillet, Plans Commercial Launch in 2025

Forsea Foods, a cultivated seafood startup from Israel, has unveiled what it claims is the world’s first cultivated eel prototype. According to the startup, the cultivated eel delivers the delicate texture and flavorful taste of the Japanese unagi eel (Anguilla japonica), renowned for its tenderness and rich flavor. To demonstrate the potential of its new development, Forsea worked with chef Katsumi Kusumoto of Saido, a popular vegan restaurant in Tokyo, to craft two traditional Japanese dishes — unagi kabayaki (marinated grilled eel over rice) and unagi nigiri. Since tastings of cultivated meat are not yet legally allowed in Japan, the prototype has not been served or tasted at Saido restaurant as yet, verifies the company. The Forsea and Saido teams met a few times in Japan and …

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CEO BZ Goldberg (L) and Culinary R&D Director Yair Yosefi

CEO BZ Goldberg (L) and Culinary R&D Director Yair Yosefi © The Mediterranean Food Lab

Investments & Finance

The Mediterranean Food Lab Secures $17M to Make Plant-Based Meat Delicious with Fermented Flavors 

The Mediterranean Food Lab (MFL), an Israeli company creating natural and fermented flavors and culinary ingredients to make alt meat and plant-based foods “delicious,” has raised $17 million in a series A investment round. Gullspång Re:food led the round, with other participants including previous investor PeakBridge (member of Edmond de Rothschild Private Equity), Arancia International, FoodBridge (Axel Johnson’s group), and additional investors, according to the announcement. With the new financing, the company will increase its industrial production and establish a sales team to promote and sell its fermented flavors for food service and CPG companies. “There is no way to reduce our dependency on animal protein without addressing “the flavor function” meat performs in the food system,” states the company. BZ Goldberg, CEO of MFL, shared: …

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Aleph Farms has received regulatory approval from Israel's Ministry of Health to sell its cultivated beef to the public.

© Aleph Farms

Cultivated Meat

Aleph Farms Receives World’s First Approval for Cultivated Beef, Petit Steak to Hit Israeli Restaurants Soon

Aleph Farms, a pioneer in Israel’s cultivated meat industry, announces regulatory approval from Israel’s Ministry of Health (MoH) through a “No Questions” letter, allowing the company to sell its cultivated beef to the public. This approval marks the world’s first approval for cultivated beef and positions Israel as the third country to approve cultivated meat products — after Singapore and the USA’s approval for cultivated chicken.  It is also the first green light for cultivated meat in the Middle East. “2024 stands to be a landmark year for the advancement of regulatory pathways and commercialization of cultivated meat. With this historic regulatory approval, Israel’s Ministry of Health (MoH) has firmly cemented its leadership position in introducing world-changing innovation in a way that builds trust with consumers,” said …

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