ScaleUp Bio has secured a food manufacturing license from the Singapore Food Agency (SFA) for its commercial pilot production facility in Tuas, western Singapore. 

Image courtesy of ScaleUp Bio

Cultivated, Cell-Cultured & Biotechnology

ADM’s ScaleUp Bio Secures Food Manufacturing License for Novel Proteins in Singapore

ScaleUp Bio, Singapore’s pioneer provider of CDMO services for microbial and precision fermentation, has secured a food manufacturing license from the Singapore Food Agency (SFA) for its commercial pilot production facility in Tuas, western Singapore.  The FSA ensures that food production practices meet established safety standards by inspecting infrastructure and facilities. It also requires proper training, collaboration, and regulatory adherence to maintain high hygiene and operational quality levels. The company states that this milestone positions it as one of the few approved CDMOs offering fermentation services at 10,000 L for food ingredients worldwide. Francisco Codoñer, CEO of ScaleUp Bio, shares, “ScaleUp Bio’s value proposition offers anyone with the next best concept in food to bring that idea to reality, and to pilot stage commercial production in Singapore, backed by a …

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Oobli and Grupo Bimbo have partnered to incorporate sweet proteins into baked goods.

© Oobli

Fermentation

Oobli’s Microbial Proteins to Sweeten Bimbo’s Baked Goods in a “Completely New Way”

California’s Oobli has partnered with Grupo Bimbo, a Mexican multinational food company touted as the largest bakery company in the United States and with a presence in 33+ countries, to introduce into baked goods its ultra-sweet proteins made with precision fermentation. This collaboration marks Oobli’s first global CPG partnership and Grupo Bimbo’s first time testing sweet proteins in products. Bimbo owns Oroweat, New York Bakery Co., and Entenmann’s, among other brands.  Oobli’s novel microbial proteins, which recently achieved GRAS (Generally Recognized as Safe) status, are described as natural sweeteners that, unlike traditional sugar, do not lead to diabetes, obesity, or sugar cravings because they are digested as protein rather than carbohydrates.  Ali Wing, CEO of Oobli, commented, “Sweet proteins have the potential to revolutionize sweetness and are a completely new way to think about how we …

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daisy lab's team

© Image courtesy of Daisy Lab

Fermentation

Yeast Instead of Cows: Daisy Lab Obtains EPA Approval to Scale Whey Proteins

New Zealand’s precision fermentation biotech Daisy Lab announces that the Environmental Protection Authority (EPA) has approved the expansion of its dairy protein platform to 5,000 L. The endorsement follows the successful production of animal-identical whey proteins in 10 L fermenters announced in January. Day Lab states that this approval marks another significant milestone in scaling and commercializing its technology, enabling it to construct a pilot facility.  CSO and co-founder Dr. Nicole Freed highlights the role of the EPA in helping Daisy Lab deal with the legal aspects related to genetic technologies. She shares: “We invested significant time and resources into preparing our application, and it’s gratifying to see our efforts pay off. This is a crucial step forward for Daisy Lab and for precision fermentation technology in New …

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A pizza with animal-free mozzarella

© New Culture

Cheese Alternatives

New Culture Partners with CJ CheilJedang to Streamline Costs of Animal-Free Mozzarella

Californian animal-free cheese producer New Culture announces a partnership with its previous investor, South Korean biotech giant CJ CheilJedang. New Culture develops casein from precision fermentation to make cow-free cheeses that melt, stretch, bubble, brown, and taste like conventional cheese without the lactose, cholesterol, hormones, and antibiotics found in milk.  The partnership will focus on reducing the production cost of New Culture’s casein to obtain a competitive price for its first product, animal-free mozzarella for pizzerias. Seung June Choi, Senior Vice President of Strategic Planning at CJ CheilJedang, comments, “Since our initial investment in New Culture in 2022, the CJ CheilJedang team has continued to be impressed by the company’s technical progress, robust bioprocess, and global ambition in the animal-free dairy industry.” Expertise to fuel …

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fermentation

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Cultivated, Cell-Cultured & Biotechnology

Report Identifies 5 Disruptive Technologies to Shake Up Fermentation Industry

Following a comprehensive review of the fermentation sector, Lever VC, a leading venture capital firm specializing in alternative protein investments, announces the release of its latest report highlighting the top technologies that could advance the production of fermented food and ingredients. Lever VC argues that despite notable advancements in CRISPR gene editing, AI and machine learning for bioinformatics systems, and high-throughput screening technologies, challenges remain in scaling up biological processes and lowering expenses to reach price parity with animal products. The new report pinpoints five cutting-edge technologies that offer potential solutions to overcome existing barriers to transform the growing biomass and precision fermentation industries: 1. Organism strain development with potential to increase productivity 10X Different methods, such as artificial intelligence/machine learning-trained algorithms or trial-and-error approaches, promise …

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TurtleTree has secured its first commercial partnership with Cadence Performance Coffee, a company dedicated to enhancing overall human performance.

©TurtleTree

Fermentation

TurtleTree’s Animal-Free Lactoferrin in Functional Espresso Marks First Commercial Partnership

Singaporean precision fermentation company TurtleTree announces it has secured its first commercial partnership with the US company Cadence Cold Brew to launch a functional espresso under the brand Cadence Performance Coffee. The companies have teamed up to introduce this innovative espresso shot range designed to improve athletic performance, featuring TurtleTree’s LF+ — the world’s first animal-free lactoferrin.   The LF+ espresso shot will offer athletes a convenient way to access the benefits of lactoferrin, which supports iron regulation, immune function, and gut health. Moreover, the LF+ can help counteract the negative effects of caffeine on zinc and iron absorption, ensuring that the body still gets access to these important nutrients, explains the biotech. This partnership comes only six months after TurtleTree obtained its self-GRAS status (generally …

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A foto of a dandelion. California-based Shiru launches ProteinDiscovery.ai, the world's first protein marketplace and discovery platform. 

© Shiru

Protein

Shiru Launches ProteinDiscovery.ai, the “World’s First” Protein Marketplace Touted as the Amazon of Proteins

California-based Shiru, an AI-enabled startup developing performance ingredients, announces the launch of what it claims to be the world’s first protein marketplace and discovery platform, ProteinDiscovery.ai. Shiru‘s new platform catalogs millions of molecules by sequence, metadata, performance, and functional use. It allows users to discover, test, and purchase molecules for food, agriculture, personal care, and advanced material applications. Dr. Jasmin Hume, Shiru’s founder and CEO, shares: “With ProteinDiscovery.ai we’ve made the world of natural proteins for industrial applications accessible. We’ve even added the ability for users to easily purchase samples, creating the ‘Amazon for proteins.’” Saving time and money Described as a first of its kind in the industry, ProteinDiscovery.ai allows users to access and utilize advanced AI in an easy-to-use web to search for ingredients and develop new products. It …

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MycoTechnology unveils sweet protein that can replace sugar and artificial sweeteners

© Getty Images (supplied by MycoTechnology)

Fermentation

MycoTechnology’s Honey Truffle Sweetener on Track to Revolutionize Sugar Reduction

Mycelial fermentation leader MycoTechnology announces significant progress in scaling production and ensuring the safety of the first-ever honey truffle sweetener.  The new product, made from a sweet protein found in honey truffles discovered only a year ago, is described as a game-changing alternative to sugar and artificial sweeteners. It has a clean taste profile and is 1000 to 2500 times sweeter than sucrose. Leveraging precision fermentation, MycoTechnology claims to have successfully scaled production from a lab bench to 3000 L tanks. Moreover, according to the announcement, the company’s team is improving production and developing efficient strains to make the honey truffle sweetener economically competitive with similar products.  Ranjan Patnaik, MycoTechnology’s CTO, comments, “Our team has achieved remarkable results, exceeding initial expectations for speed of scale-up, mechanistic understanding …

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Solar Foods launches first -ever Gelato made with its microbial protein

© Solar Foods

Fermentation

Historic Moment in Food Production: Solar Foods Opens World’s First Commercial-Scale Air Protein Facility

Finnish air protein Solar Foods announces the official launch of its highly anticipated Factory 01 in Vantaa, Finland. Claimed as the world’s first factory growing food out of thin air, the new plant will commercially produce 160 tons annually of the company’s flagship protein, Solein, paving the way for the next generation of sustainable products.  Produced leveraging a microorganism, CO2, and electricity and described as a nutritious and versatile protein, Solein has been only released in small batches from the company’s pilot laboratory in Espoo, near Helsinki.  Solar Foods’ CEO and co-founder, Pasi Vainikka, shares: “We will be able to deliver quantities that allow food producers to create large batches of Solein-powered products for the first time. “While we have been able to offer consumers a small …

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A collage of the brands that have partnered with Spiber

© Spiber Inc.

Cultivated, Cell-Cultured & Biotechnology

Spiber Raises Over JPY10 Billion for Mass Production of Fermented Proteins for Materials

Spiber Inc., a Japanese biotech “brewing” sustainable materials for the fashion, automotive, and personal care industry, announces it has raised over JPY10 billion (around $65M) in equity financing. Spiber has raised a total funding of $489 million over 9 rounds. The funding, which included additional investments from existing shareholders, will allow the company to accelerate mass production of its innovative Brewed Protein materials and facilitate global sales.  Founded in 2007, Spiber uses precision fermentation and polymer and material science to develop protein-based alternatives to animal and petrochemical materials. Its polymers can be used to make spider silk, wool, cashmere, leather, fur, and more. The company already operates biomanufacturing plants in Thailand and is building another in Iowa, USA. Kazuhide Sekiyama, Director and Representative Executive Officer …

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liberation labs precision fermentation plant

© Liberation Labs

Cultivated, Cell-Cultured & Biotechnology

Agronomics Invests $10M in Liberation Labs to Advance its 600,000 L Precision Fermentation Facility

Agronomics Limited (LSE: ANIC), the UK’s leading VC company focused on cellular agriculture and biomanufacturing, has invested $10 million in its portfolio company, Liberation Labs Holdings, a US biotechnology firm focused on large-scale precision fermentation manufacturing. The investment was part of a $12.5 million financing round, which was made through a Secured Convertible Promissory Note (SCPN) using Agronomics’ existing cash resources. Previous investor Siddhi Capital also joined the round to help fund the ongoing construction of Liberation Labs’s facility in Richmond, Indiana. Agronomics has invested $17.6 million in Liberation Labs, including $7 million to join the CDMO company on its mission to propel fermented proteins and other bio-based solutions. According to the announcement, Agronomics now holds a 37.5% stake in Liberation Labs. Jim Mellon, Executive …

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Clean Food Group (CFG) has raised £2.5 million to accelerate the commercial launch of its precision fermentation-derived, non-GMO alternative to palm oil by 2025.

Chris Chuck – Yeast alternative to palm oil © University of Bath

Fermentation

Clean Food Group Secures £2.5M to Launch Non-GMO Alternative to Palm Oil by 2025

UK-based biotech firm Clean Food Group (CFG) has raised £2.5 million to accelerate the commercial launch of its yeast-derived, non-GMO alternative to palm oil by 2025. Said to be equivalent to high-oleic palm oil, CFG’s go-to-market product is designed as a drop-in ingredient suitable for baked goods, confectionery, and cosmetics applications. CFG believes it can introduce its novel food product to the UK and EU markets, as the regulatory process for non-GMOs is less strict than that for genetically modified foods. The UK VC Clean Growth Fund, which supports climate tech businesses that reduce carbon emissions and tackle the climate crisis, made this significant investment in CFG — bringing the company’s total raised funds to £13 million.  So far, CFG has received funding from the cell ag-focused VC …

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Crepes filled with animal-free cream

© Imagindairy

Fermentation

Imagindairy and Ginkgo Bioworks Receive Grant to Accelerate the Launch of Cow-Free Dairy Proteins

Israeli animal-free dairy protein developer Imagindairy and Ginkgo Bioworks (NYSE: DNA), a Boston-based biotech specializing in cell programming, announce a partnership to accelerate the introduction of a new wave of cow-free dairy. A joint grant from the Board of Governors of the Israel-US Binational Industrial Research and Development (BIRD) Foundation has partly funded the companies’s multiyear program to commercialize non-whey proteins. The collaboration will leverage Ginkgo Bioworks’ Protein Expression Services and Imagindairy’s process development and scale-up expertise to develop and manufacture animal-free whey cost-effectively to reach prices similar to dairy proteins.  Ginkgo is also working with the Chicago-based alt-seafood producer Aqua Cultured Foods to improve the economics and functions of its microbial strains for large-scale operations. Jennifer Wipf, CEO at Ginkgo Bioworks, shares, “Being awarded this …

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Strive FREEMILK Whole, an alternative milk crafted with Perfect Day's whey protein, has launched in partnership with Florida coffee roasters Oceana Coffee at the 2024 Miami Open.

Image courtesy of Strive FREEMILK

Cultivated, Cell-Cultured & Biotechnology

Strive Milk is Served at the Miami Open, Becoming First Animal-Free Milk at Major Sporting Event

Strive FREEMILK Whole, an alternative milk crafted with Perfect Day‘s sustainable whey protein, is being served in partnership with Florida coffee roasters Oceana Coffee at the 2024 Miami Open. This launch represents the first animal-free milk made with precision fermentation protein served at a major sporting event, marking a huge milestone for the alt dairy category, gaining mainstream visibility and recognition beyond just being available online or in stores. Strive Nutrition Corp., the company behind Strive FREEMILK, states that its “milk-like” product will revolutionize the coffee experience at the Miami Open thanks to its rich flavor, high protein content, sustainability, and ethical standards. MichaelAnn Cohlmia, Creative Director at Strive Nutrition, shared, “We are thrilled to introduce Strive FREEMILK to the tennis fans and coffee enthusiasts …

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Four cows in a field

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Cultivated, Cell-Cultured & Biotechnology

Toronto Startups AuX Labs & Genuine Taste Join BioCreate Accelerator to Create Alternatives to Cheese and Beef

Two cutting-edge biotech startups from Ontario, Canada — AuX Labs and Genuine Taste — have been selected to join BioCreate, an accelerator program that supports innovative companies in the health, food, agriculture, and cleantech sectors. AuX Lab was founded in 2021 by Ted Jin to create affordable bioidentical animal proteins using precision fermentation and engineered yeasts. The company is working to develop yeast strains with high protein-yielding capabilities and a bioprocess fueled by low-cost feedstocks established in “capital-light” fermentation facilities.  AuX Lab’s first protein — milk casein — is used to create animal-free cheese with the same taste and melting and stretching functionalities as dairy cheese. The startup has raised $3 million in a seed round from investors Bluestein Ventures, Congruent Ventures, and Flying Fish Partners. Meanwhile, Genuine …

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Oobli, a Sweet protein developer from California, formerly Joywell Foods, has received what it claims to be the FDA's first "No questions" letter for a brazzein protein made with precision fermentation.

© Oobli

Fermentation

Oobli Receives FDA No Questions Letter for Oubli Fruit Sweet Protein Made with Precision Fermention

Oobli, formerly Joywell Foods, a sweet protein developer from California, USA, announces that it has received what it claims to be the FDA’s first “No questions” letter for its brazzein protein made with precision fermentation. The US Food and Drug Administration letter confirms Oobli’s self-affirmed GRAS (generally recognized as safe) status for Oubli Fruit Sweet Protein and supports its use as a food and beverage ingredient in the USA. Ali Wing, CEO of Oobli, shares, “The “No questions” letter from the FDA is a further testament to the strong potential that sweet proteins have to disrupt our global dependence on sugar and alternative sweeteners. The Oubli Fruit Sweet Protein can be safely used in various foods with support from the general scientific community and the …

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Raffael Wohlgensinger and Hille van der Kaa – Image courtesy of Those Vegan Cowboys

Cheese Alternatives

Formo and Those Vegan Cowboys Reveal “First-of-its-Kind” Collab to Expedite Production of Cow-Free Cheese

Two precision fermentation companies — Germany’s Formo and Those Vegan Cowboys from Belgium — today announce a strategic R&D alliance to accelerate the production of animal-free casein and finally retire cows from cheese production. This “first-of-its-kind” collaboration will bring together over 60 world-leading scientists to create a “powerful and experienced” research team that will improve technological efficiency, including efforts in strain engineering, bioprocessing, and large-scale production of caseins. The companies believe that by joining forces, they can more quickly achieve price parity with milk proteins, thus making cow-free cheese more competitive and accessible to consumers. The companies explain that they plan to combine their manufacturing outputs to achieve economies of scale; nevertheless, each firm will maintain its distinct identity and market its lines of cow-free …

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Cauldron raises $9.5M AUD Series A to scale its continuous hyper-fermentation technology

Michele Stansfield, co-founder and CEO of Cauldron © Cauldron Ferm

Cultivated, Cell-Cultured & Biotechnology

Investors Back Cauldron’s Plans for Global Network of Precision Fermentation Facilities to Tune of $6.25M

Precision fermentation company Cauldron Ferm announces it has secured AUD 9.5 million ($6.25M) in a series A round led by Horizons Ventures. SOSV, In-Q-Tel, and previous investor Main Sequence also participated in the round, bringing Cauldron’s total raised funds to $20 million.  Precision fermentation is crucial for increasing food production without expanding agricultural land while it addresses sustainability and security issues. The United Nations predicts a 70% increase in food production by 2025 to support the rising population. Cauldron says that it aims to deploy its cost-effective, continuous fermentation technology in a network of worldwide rural facilities to develop biobased products and contribute to meeting the growing global food, cosmetics, and materials demand.  Chis Liu of Horizons Ventures, comments: “Precision fermentation is an amazing technology, because it enables bio based production of …

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A precision fermentation derived fat

Image courtesy of Melt&Marble

Fermentation

Melt&Marble Unlocks Commercial-Scale Production for Animal-Free Designer Fat, Sets Sights on US Market by 2025

Melt&Marble, a Swedish precision fermentation company that specializes in designer fats for food and other applications, has revealed new headquarters with expanded R&D and production capabilities. The facility features “state-of-the-art” molecular biology and microbiology labs, pilot-scale bioreactors, and a food application kitchen to test its “meat-like” fat in meat alternatives and other products. Melt&Marble says that it has already successfully scaled its production to one cubic meter. However, with the new capabilities, the company believes it will be able to achieve commercial-scale production beyond its previous milestone. Anastasia Krivoruchko, co-founder and CEO of Melt&Marble, says: “We are excited about the achievements to date. In the last months, we constantly improved key performance indicators related to rate, titre and yield, successfully achieving metrics relevant for commercial-scale and …

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Image courtesy of Swan Neck Bio

Cultivated, Cell-Cultured & Biotechnology

Swan Neck Bio Launches FlexCell for Fast and Affordable Fermentation Scaling

Swan Neck Bio, a spin-off from White Labs Copenhagen, a global leader in fermentation since 1995, has officially entered the market to unlock the biomanufacturing capacity of precision fermentation and biomass companies. Headquartered in Copenhagen, with supporting labs and production capabilities in the USA (California and North Carolina), Swan Neck Bio leverages a patented “breakthrough” technology developed by White Labs.  Called FlexCell, the technology allows companies to trial, validate, and scale microorganisms from the lab to 1,000 L more quickly and affordably. Fábio Faria-Oliveira, CSO of the company, shares: “Our dream is a world where there are no constraints to the innovative biosolutions our world urgently needs if we’re going to support a constantly growing population.”  Scaling without risks Troels Prahl, a microbiologist with over 20 …

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