MycoTechnology unveils sweet protein that can replace sugar and artificial sweeteners

© Getty Images (supplied by MycoTechnology)

Fermentation

MycoTechnology’s Honey Truffle Sweetener on Track to Revolutionize Sugar Reduction

Mycelial fermentation leader MycoTechnology announces significant progress in scaling production and ensuring the safety of the first-ever honey truffle sweetener.  The new product, made from a sweet protein found in honey truffles discovered only a year ago, is described as a game-changing alternative to sugar and artificial sweeteners. It has a clean taste profile and is 1000 to 2500 times sweeter than sucrose. Leveraging precision fermentation, MycoTechnology claims to have successfully scaled production from a lab bench to 3000 L tanks. Moreover, according to the announcement, the company’s team is improving production and developing efficient strains to make the honey truffle sweetener economically competitive with similar products.  Ranjan Patnaik, MycoTechnology’s CTO, comments, “Our team has achieved remarkable results, exceeding initial expectations for speed of scale-up, mechanistic understanding …

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Solar Foods launches first -ever Gelato made with its microbial protein

© Solar Foods

Fermentation

Historic Moment in Food Production: Solar Foods Opens World’s First Commercial-Scale Air Protein Facility

Finnish air protein Solar Foods announces the official launch of its highly anticipated Factory 01 in Vantaa, Finland. Claimed as the world’s first factory growing food out of thin air, the new plant will commercially produce 160 tons annually of the company’s flagship protein, Solein, paving the way for the next generation of sustainable products.  Produced leveraging a microorganism, CO2, and electricity and described as a nutritious and versatile protein, Solein has been only released in small batches from the company’s pilot laboratory in Espoo, near Helsinki.  Solar Foods’ CEO and co-founder, Pasi Vainikka, shares: “We will be able to deliver quantities that allow food producers to create large batches of Solein-powered products for the first time. “While we have been able to offer consumers a small …

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A collage of the brands that have partnered with Spiber

© Spiber Inc.

Cultivated, Cell-Cultured & Biotechnology

Spiber Raises Over JPY10 Billion for Mass Production of Fermented Proteins for Materials

Spiber Inc., a Japanese biotech “brewing” sustainable materials for the fashion, automotive, and personal care industry, announces it has raised over JPY10 billion (around $65M) in equity financing. Spiber has raised a total funding of $489 million over 9 rounds. The funding, which included additional investments from existing shareholders, will allow the company to accelerate mass production of its innovative Brewed Protein materials and facilitate global sales.  Founded in 2007, Spiber uses precision fermentation and polymer and material science to develop protein-based alternatives to animal and petrochemical materials. Its polymers can be used to make spider silk, wool, cashmere, leather, fur, and more. The company already operates biomanufacturing plants in Thailand and is building another in Iowa, USA. Kazuhide Sekiyama, Director and Representative Executive Officer …

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liberation labs precision fermentation plant

© Liberation Labs

Cultivated, Cell-Cultured & Biotechnology

Agronomics Invests $10M in Liberation Labs to Advance its 600,000 L Precision Fermentation Facility

Agronomics Limited (LSE: ANIC), the UK’s leading VC company focused on cellular agriculture and biomanufacturing, has invested $10 million in its portfolio company, Liberation Labs Holdings, a US biotechnology firm focused on large-scale precision fermentation manufacturing. The investment was part of a $12.5 million financing round, which was made through a Secured Convertible Promissory Note (SCPN) using Agronomics’ existing cash resources. Previous investor Siddhi Capital also joined the round to help fund the ongoing construction of Liberation Labs’s facility in Richmond, Indiana. Agronomics has invested $17.6 million in Liberation Labs, including $7 million to join the CDMO company on its mission to propel fermented proteins and other bio-based solutions. According to the announcement, Agronomics now holds a 37.5% stake in Liberation Labs. Jim Mellon, Executive …

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Clean Food Group (CFG) has raised £2.5 million to accelerate the commercial launch of its precision fermentation-derived, non-GMO alternative to palm oil by 2025.

Chris Chuck – Yeast alternative to palm oil © University of Bath

Fermentation

Clean Food Group Secures £2.5M to Launch Non-GMO Alternative to Palm Oil by 2025

UK-based biotech firm Clean Food Group (CFG) has raised £2.5 million to accelerate the commercial launch of its yeast-derived, non-GMO alternative to palm oil by 2025. Said to be equivalent to high-oleic palm oil, CFG’s go-to-market product is designed as a drop-in ingredient suitable for baked goods, confectionery, and cosmetics applications. CFG believes it can introduce its novel food product to the UK and EU markets, as the regulatory process for non-GMOs is less strict than that for genetically modified foods. The UK VC Clean Growth Fund, which supports climate tech businesses that reduce carbon emissions and tackle the climate crisis, made this significant investment in CFG — bringing the company’s total raised funds to £13 million.  So far, CFG has received funding from the cell ag-focused VC …

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Crepes filled with animal-free cream

© Imagindairy

Fermentation

Imagindairy and Ginkgo Bioworks Receive Grant to Accelerate the Launch of Cow-Free Dairy Proteins

Israeli animal-free dairy protein developer Imagindairy and Ginkgo Bioworks (NYSE: DNA), a Boston-based biotech specializing in cell programming, announce a partnership to accelerate the introduction of a new wave of cow-free dairy. A joint grant from the Board of Governors of the Israel-US Binational Industrial Research and Development (BIRD) Foundation has partly funded the companies’s multiyear program to commercialize non-whey proteins. The collaboration will leverage Ginkgo Bioworks’ Protein Expression Services and Imagindairy’s process development and scale-up expertise to develop and manufacture animal-free whey cost-effectively to reach prices similar to dairy proteins.  Ginkgo is also working with the Chicago-based alt-seafood producer Aqua Cultured Foods to improve the economics and functions of its microbial strains for large-scale operations. Jennifer Wipf, CEO at Ginkgo Bioworks, shares, “Being awarded this …

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Strive FREEMILK Whole, an alternative milk crafted with Perfect Day's whey protein, has launched in partnership with Florida coffee roasters Oceana Coffee at the 2024 Miami Open.

Image courtesy of Strive FREEMILK

Cultivated, Cell-Cultured & Biotechnology

Strive Milk is Served at the Miami Open, Becoming First Animal-Free Milk at Major Sporting Event

Strive FREEMILK Whole, an alternative milk crafted with Perfect Day‘s sustainable whey protein, is being served in partnership with Florida coffee roasters Oceana Coffee at the 2024 Miami Open. This launch represents the first animal-free milk made with precision fermentation protein served at a major sporting event, marking a huge milestone for the alt dairy category, gaining mainstream visibility and recognition beyond just being available online or in stores. Strive Nutrition Corp., the company behind Strive FREEMILK, states that its “milk-like” product will revolutionize the coffee experience at the Miami Open thanks to its rich flavor, high protein content, sustainability, and ethical standards. MichaelAnn Cohlmia, Creative Director at Strive Nutrition, shared, “We are thrilled to introduce Strive FREEMILK to the tennis fans and coffee enthusiasts …

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Four cows in a field

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Cultivated, Cell-Cultured & Biotechnology

Toronto Startups AuX Labs & Genuine Taste Join BioCreate Accelerator to Create Alternatives to Cheese and Beef

Two cutting-edge biotech startups from Ontario, Canada — AuX Labs and Genuine Taste — have been selected to join BioCreate, an accelerator program that supports innovative companies in the health, food, agriculture, and cleantech sectors. AuX Lab was founded in 2021 by Ted Jin to create affordable bioidentical animal proteins using precision fermentation and engineered yeasts. The company is working to develop yeast strains with high protein-yielding capabilities and a bioprocess fueled by low-cost feedstocks established in “capital-light” fermentation facilities.  AuX Lab’s first protein — milk casein — is used to create animal-free cheese with the same taste and melting and stretching functionalities as dairy cheese. The startup has raised $3 million in a seed round from investors Bluestein Ventures, Congruent Ventures, and Flying Fish Partners. Meanwhile, Genuine …

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Oobli, a Sweet protein developer from California, formerly Joywell Foods, has received what it claims to be the FDA's first "No questions" letter for a brazzein protein made with precision fermentation.

© Oobli

Fermentation

Oobli Receives FDA No Questions Letter for Oubli Fruit Sweet Protein Made with Precision Fermention

Oobli, formerly Joywell Foods, a sweet protein developer from California, USA, announces that it has received what it claims to be the FDA’s first “No questions” letter for its brazzein protein made with precision fermentation. The US Food and Drug Administration letter confirms Oobli’s self-affirmed GRAS (generally recognized as safe) status for Oubli Fruit Sweet Protein and supports its use as a food and beverage ingredient in the USA. Ali Wing, CEO of Oobli, shares, “The “No questions” letter from the FDA is a further testament to the strong potential that sweet proteins have to disrupt our global dependence on sugar and alternative sweeteners. The Oubli Fruit Sweet Protein can be safely used in various foods with support from the general scientific community and the …

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Raffael Wohlgensinger and Hille van der Kaa – Image courtesy of Those Vegan Cowboys

Cheese Alternatives

Formo and Those Vegan Cowboys Reveal “First-of-its-Kind” Collab to Expedite Production of Cow-Free Cheese

Two precision fermentation companies — Germany’s Formo and Those Vegan Cowboys from Belgium — today announce a strategic R&D alliance to accelerate the production of animal-free casein and finally retire cows from cheese production. This “first-of-its-kind” collaboration will bring together over 60 world-leading scientists to create a “powerful and experienced” research team that will improve technological efficiency, including efforts in strain engineering, bioprocessing, and large-scale production of caseins. The companies believe that by joining forces, they can more quickly achieve price parity with milk proteins, thus making cow-free cheese more competitive and accessible to consumers. The companies explain that they plan to combine their manufacturing outputs to achieve economies of scale; nevertheless, each firm will maintain its distinct identity and market its lines of cow-free …

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Cauldron raises $9.5M AUD Series A to scale its continuous hyper-fermentation technology

Michele Stansfield, co-founder and CEO of Cauldron © Cauldron Ferm

Cultivated, Cell-Cultured & Biotechnology

Investors Back Cauldron’s Plans for Global Network of Precision Fermentation Facilities to Tune of $6.25M

Precision fermentation company Cauldron Ferm announces it has secured AUD 9.5 million ($6.25M) in a series A round led by Horizons Ventures. SOSV, In-Q-Tel, and previous investor Main Sequence also participated in the round, bringing Cauldron’s total raised funds to $20 million.  Precision fermentation is crucial for increasing food production without expanding agricultural land while it addresses sustainability and security issues. The United Nations predicts a 70% increase in food production by 2025 to support the rising population. Cauldron says that it aims to deploy its cost-effective, continuous fermentation technology in a network of worldwide rural facilities to develop biobased products and contribute to meeting the growing global food, cosmetics, and materials demand.  Chis Liu of Horizons Ventures, comments: “Precision fermentation is an amazing technology, because it enables bio based production of …

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A precision fermentation derived fat

Image courtesy of Melt&Marble

Fermentation

Melt&Marble Unlocks Commercial-Scale Production for Animal-Free Designer Fat, Sets Sights on US Market by 2025

Melt&Marble, a Swedish precision fermentation company that specializes in designer fats for food and other applications, has revealed new headquarters with expanded R&D and production capabilities. The facility features “state-of-the-art” molecular biology and microbiology labs, pilot-scale bioreactors, and a food application kitchen to test its “meat-like” fat in meat alternatives and other products. Melt&Marble says that it has already successfully scaled its production to one cubic meter. However, with the new capabilities, the company believes it will be able to achieve commercial-scale production beyond its previous milestone. Anastasia Krivoruchko, co-founder and CEO of Melt&Marble, says: “We are excited about the achievements to date. In the last months, we constantly improved key performance indicators related to rate, titre and yield, successfully achieving metrics relevant for commercial-scale and …

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Image courtesy of Swan Neck Bio

Cultivated, Cell-Cultured & Biotechnology

Swan Neck Bio Launches FlexCell for Fast and Affordable Fermentation Scaling

Swan Neck Bio, a spin-off from White Labs Copenhagen, a global leader in fermentation since 1995, has officially entered the market to unlock the biomanufacturing capacity of precision fermentation and biomass companies. Headquartered in Copenhagen, with supporting labs and production capabilities in the USA (California and North Carolina), Swan Neck Bio leverages a patented “breakthrough” technology developed by White Labs.  Called FlexCell, the technology allows companies to trial, validate, and scale microorganisms from the lab to 1,000 L more quickly and affordably. Fábio Faria-Oliveira, CSO of the company, shares: “Our dream is a world where there are no constraints to the innovative biosolutions our world urgently needs if we’re going to support a constantly growing population.”  Scaling without risks Troels Prahl, a microbiologist with over 20 …

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Fermify's team

Fermify's team - Image courtesy of Fermify

Fermentation

Fermify Offers Animal-Free Casein Samples to Industry Partners to “Unlock” Dairy-Free Creations

Fermify, an Austrian precision fermentation company set to revolutionize dairy production, announces that it now provides industry companies with samples of its liquid form animal-free casein to create “groundbreaking” dairy-free products. Fermify’s casein is said to offer a purity level of 94%, while its functionality — taste, meltability, and structure — rivals that of animal-based proteins, as shown in successful pilot-scale testings.  With this initiative, Fermify aims to spark interest and collaboration to accelerate the development of animal-free cheese and dairy products that meet top-notch quality and functionality standards and taste great. “We eagerly anticipate the exciting possibilities that our samples will unlock in the traditional dairy industry, inspiring new creations and advancements in dairy product development,” states Fermify. Cost-effective production Founded in November 2021 …

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(Left to Right): Dirk Steinhäuser, Vice Head, Dresden Engineering Office of Glatt Group; Alaa Al Ali, Shareholder and Member of the Board of Novel Foods Group LLC; Matthew Robin, Member of the Board of Bioengineering AG.

(Left to Right): Dirk Steinhäuser, Vice Head, Dresden Engineering Office of Glatt Group; Alaa Al Ali, Shareholder and Member of the Board of Novel Foods Group LLC; Matthew Robin, Member of the Board of Bioengineering AG © Novel Foods Group

Fermentation

Novel Foods Group Reveals $500M Precision Fermentation Hub to Produce Brazzein

Novel Foods Group, an Abu Dhabi-based company producing sweet proteins, has announced a landmark agreement to build the first phase of a $500 million biotech production hub in the United Arab Emirates (UAE) focused on precision fermentation. The deal was signed between Novel Foods Group, which is a subsidiary of the investment conglomerate Gewan Holding, Glatt Group, a German expert in plant engineering, BioEngineering AG, a Swiss company specialized in engineering and design, and CB Consultancy AG, a Swiss company engineering solutions for cutting-edge industries. The new production site will initially develop brazzein, a sweet-tasting protein found in the fruit of the native West African Oubli plant, that is said to be significantly sweeter than sugar. Local people have used and eaten the fruit for many …

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Cellular Agriculture Australia (CAA) announces the release of a pioneering Regulation Resource Hub to help cell ag companies streamline their food safety application process for novel foods.

© Cellular Agriculture Australia (CAA)

Fermentation

This Week in Australia’s Cell Ag Sector: Cauldron Ferm and QUT Lead Efforts to Scale Precision Fermentation Production

We are covering this week’s developments in Australia’s cellular agriculture ecosystem, with Cauldron Ferm and Queensland University of Technology (QUT) leading efforts to establish a global infrastructure for scaling up precision fermentation production for the Asia-Pacific region. Cauldron Ferm Receives License to Produce Animal-Free Proteins at 10,000 L Scale Precision fermentation company Cauldron Ferm announces that it has received a license from the Office of the Gene Technology Regulator (OGTR) to produce animal-free proteins at a 10,000 L scale. The DIR200 license allows Cauldron to utilize its proprietary hyper-fermentation technology and Pichia Pastoris yeast to produce dairy, egg, and spider-silk proteins. The OGTR, part of the Australian Government’s Department of Health and Aged Care, conducted the pertinent risk and management assessments, determining that Cauldron’s hyper-fermentation process is …

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Vivici fermentation unit

© Vivici

Cultivated, Cell-Cultured & Biotechnology

Global Biomanufacturing Capacity Must Grow 20X to Reach Industry Growth of $200 Billion by 2040, Says New Report

A recent report, co-authored by the New York-based biotech firm Synonym and Boston Consulting Group, has outlined a roadmap for the biomanufacturing industry, predicting a potential explosion to a $200 billion market in specialty sectors over the next ten years. The report Breaking the Cost Barrier on Biomanufacturing encourages the transition to biomanufacturing to address issues of sustainability and cost-efficiency in current industrial production methods. However, the report’s estimated $200 billion market value is focused on precision fermentation to produce food ingredients, chemicals, and chemical precursors. According to the authors, the figure is considered conservative and reflects only a fraction of the potential for growth within the industry. “The big problem—and the reason that precision fermentation remains an underused technology despite continuing advances in genome engineering and …

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New Culture block of grating cheese on chopping board

© New Culture

Fermentation

What is Precision Fermentation? Precision Fermentation Alliance and Food Fermentation Europe Reveal Expanded Definition 

Trade organizations the Precision Fermentation Alliance (PFA) and Food Fermentation Europe (FFE) have revealed a new expanded definition of precision fermentation (PF) to provide clarity on its unique characteristics, its differences from other fermentation-based technologies, and its applications. With biomass fermentation, traditional fermentation, and other technologies like molecular farming and plant cell culture emerging to make novel ingredients for food, the collaboration aims to help stakeholders, regulators, and consumers understand the basics of PF technology. Recently, precision fermentation has been in the spotlight, with various companies announcing the launch of animal-free dairy proteins, human milk fat analogs, and proteins for eggs. However, before its emergence for alt proteins, the technology has been safely used in food and medicine for over three decades to make insulin, rennet …

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Adamo Foods' fungi-based steak

© Adamo Foods

Cultivated, Cell-Cultured & Biotechnology

UK Government Invests £12M in Fermentation Hub for Alternative Proteins

The UK government has announced a £12 million investment in the Microbial Food Hub, a research centre focusing on fermentation-based foods to develop sustainable and innovative alternatives to animal products. Led by Dr. Rodrigo Ledesma-Amaro at Imperial College London, the hub will explore technologies that use microorganisms, such as biomass fermentation to develop mycoproteins and precision fermentation to create bioidentical egg or dairy proteins and other ingredients. The hub will also explore traditional fermentation to improve the nutritional quality of plant-based foods. Experts from various universities, including the University of Reading, the University of Kent, the University of Aberystwyth, the University of Cambridge, and Rothamsted Research, will collaborate on the project along with industrial and food industry partners. The hub will receive the funds from …

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Fengru Lin, TurtleTree CEO and co-founder

Fengru Lin, TurtleTree CEO and co-founder © TurtleTree

Fermentation

TurtleTree Secures First-Ever Vegan Certification in Precision Fermentation Dairy

After obtaining self-GRAS status last November for its animal-free lactoferrin, LF+, TurtleTree, a Singaporean biotech company operating in California, USA, announces that the product has officially obtained vegan certification.  TrutleTree’s protein and manufacturing process has been certified by Vegan Action, the leading vegan certification provider in the US. The vegan stamp ensures that consumers can trust the absence of animal products, byproducts, and animal testing in their products. According to the Singaporean biotech, this milestone establishes it as the first precision fermentation dairy company globally to obtain vegan certification. Meanwhile, it also marks the first time that Vegan Action gives the stamp to a novel protein in its 24-year trajectory with more than 15,000 products Vegan Certified. Fengru Lin, CEO and co-founder of TurtleTree, comments: …

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